Biography

Assist. Prof. U.D. Dr. Tobias A. Knoch:
The work of Dr. Tobias A. Knoch at his group Biophysical Genomics at the Kirchhoff Institute for Physics, University of Heidelberg in Heidelberg, and the Biophysics Group being established by him at the Erasmus Medical Center in Rotterdam since August 2004, is focused on the determination and understanding of genome organization in general and of the human genome in particular from the DNA sequence level to the entire nuclear morphology. Therefore, approaches from theoretic physics have been combined with molecular biology in highly interdisciplinary projects ranging from advanced sequence analyses of genomes, parallel high-performance computer modeling of genomic architectures and new image analysis methods, to advanced fluorescence in situ hybridization labeling and high-resolution chromatin conformation interaction genome mapping. A major achievement was the development of an artefact-free in vivo labeling method of nuclear chromatin. Work also includes the first system-biological genome browser, the GLOBE 3D Genome Browser, and the set-up of one of the largest desktop computing grids, the Erasmus Computing Grid. These efforts resulted in several patents, peer-reviewed publications and awards, as well as the necessary knowledge in project management concerning large cooperative scientific networks, the training of students on various levels as well as communication with other collaborators from diverse interdisciplinary background. Beyond, Dr. Tobias A. Knoch is director of the ECG. Dr. Tobias A. Knoch is a co-founder of MediGRID and Services@MediGRID, both part of the German D-Grid. DR. Tobias A. Knoch is a board member of MediGRID.